Drug interactions
Entacapone + Omaveloxolone
Severity: Minor
Entacapone and Omaveloxolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is metabolized by CYP3A4, and inhibitors increase its exposure. Entacapone is not a recognized meaningful CYP3A4 inhibitor, so any increase is theoretical.
What this interaction means in plain words
Entacapone and Omaveloxolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entacapone belongs to Central Nervous System; Omaveloxolone belongs to Central Nervous System.
Why it happens
Theoretical CYP3A4 inhibition by entacapone; not established clinically.
What to do
Monitor liver enzymes, lipids and BNP as per omaveloxolone labeling; no empirical dose change is needed unless adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Entacapone with Omaveloxolone?
MediHelp rates the interaction as minor. Entacapone and Omaveloxolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omaveloxolone is metabolized by CYP3A4, and inhibitors increase its exposure. Entacapone is not a recognized meaningful CYP3A4 inhibitor, so any increase is theoretical.
How serious is the interaction between Entacapone and Omaveloxolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes, lipids and BNP as per omaveloxolone labeling; no empirical dose change is needed unless adverse effects emerge.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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