Drug interactions
Entacapone + Repotrectinib
Severity: Minor
Entacapone and Repotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repotrectinib is a CYP3A4 substrate, and strong or moderate CYP3A inhibitors can increase its exposure and neurologic toxicity. Entacapone is not an established CYP3A4 inhibitor, so the effect is theoretical.
What this interaction means in plain words
Entacapone and Repotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entacapone belongs to Central Nervous System; Repotrectinib belongs to Oncology.
Why it happens
Theoretical CYP3A4 inhibition by entacapone; not established clinically.
What to do
No empirical dose change is needed; monitor for dizziness, ataxia and other CNS effects of repotrectinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Entacapone with Repotrectinib?
MediHelp rates the interaction as minor. Entacapone and Repotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Repotrectinib is a CYP3A4 substrate, and strong or moderate CYP3A inhibitors can increase its exposure and neurologic toxicity. Entacapone is not an established CYP3A4 inhibitor, so the effect is theoretical.
How serious is the interaction between Entacapone and Repotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for dizziness, ataxia and other CNS effects of repotrectinib.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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