Drug interactions
Entecavir + Ethacrynic acid
Severity: Minor
Entecavir and Ethacrynic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is secreted by renal tubular transporters and may cause volume depletion and renal impairment, which could reduce entecavir clearance. Clinical evidence is lacking.
What this interaction means in plain words
Entecavir and Ethacrynic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entecavir belongs to Anti Virals; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Possible competition for tubular secretion and diuretic-induced reduction in renal function.
What to do
Monitor renal function and hydration status; adjust entecavir dose if creatinine clearance falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entecavir
- Alogliptin-metformin + Entecavir Moderate
- Canagliflozin-metformin + Entecavir Moderate
- Cidofovir + Entecavir Moderate
- Cyclosporine + Entecavir Moderate
- Dapagliflozin-metformin + Entecavir Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Entecavir Moderate
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Entecavir with Ethacrynic acid?
MediHelp rates the interaction as minor. Entecavir and Ethacrynic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethacrynic acid is secreted by renal tubular transporters and may cause volume depletion and renal impairment, which could reduce entecavir clearance. Clinical evidence is lacking.
How serious is the interaction between Entecavir and Ethacrynic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and hydration status; adjust entecavir dose if creatinine clearance falls.
What other medicines interact with Entecavir?
MediHelp also lists interactions of Entecavir with, for example, Alogliptin-metformin, Canagliflozin-metformin, Cidofovir. The full list is on the Entecavir page.
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