Drug interactions
Entecavir + Gentamicin
Severity: Moderate
Entecavir and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gentamicin is nephrotoxic and entecavir is eliminated renally by filtration and tubular secretion. Reduced renal function from gentamicin may raise entecavir exposure, and entecavir may add to renal burden.
What this interaction means in plain words
Entecavir and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entecavir belongs to Anti Virals; Gentamicin belongs to Anti Bacterial.
Why it happens
Gentamicin-induced renal impairment reduces entecavir clearance, with possible competition for renal elimination.
What to do
Monitor serum creatinine and gentamicin levels during coadministration, and adjust entecavir dosing according to creatinine clearance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Entecavir
Frequently asked questions
Can I take Entecavir with Gentamicin?
MediHelp rates the interaction as moderate. Entecavir and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gentamicin is nephrotoxic and entecavir is eliminated renally by filtration and tubular secretion. Reduced renal function from gentamicin may raise entecavir exposure, and entecavir may add to renal burden.
How serious is the interaction between Entecavir and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin levels during coadministration, and adjust entecavir dosing according to creatinine clearance.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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