Drug interactions
Entecavir + Letermovir
Severity: Minor
Entecavir and Letermovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entecavir is eliminated mainly by the kidney through filtration and active tubular secretion. Letermovir could theoretically compete for renal transport, but no meaningful rise in either drug has been established, so any clinical effect is likely small.
What this interaction means in plain words
Entecavir and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Entecavir belongs to Anti Virals; Letermovir belongs to Anti Virals.
Why it happens
Possible competition for renal tubular secretion; the effect is theoretical and not well established.
What to do
No dose change is needed. Monitor renal function periodically in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entecavir
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Entecavir with Letermovir?
MediHelp rates the interaction as minor. Entecavir and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Entecavir is eliminated mainly by the kidney through filtration and active tubular secretion. Letermovir could theoretically compete for renal transport, but no meaningful rise in either drug has been established, so any clinical effect is likely small.
How serious is the interaction between Entecavir and Letermovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor renal function periodically in patients with renal impairment.
What other medicines interact with Entecavir?
MediHelp also lists interactions of Entecavir with, for example, Alogliptin-metformin, Canagliflozin-metformin, Cidofovir. The full list is on the Entecavir page.
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