Drug interactions
Entecavir + Tacrolimus
Severity: Moderate
Entecavir and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus is nephrotoxic and can lower glomerular filtration, while entecavir relies on renal elimination. Declining kidney function may increase entecavir concentrations, and entecavir dosing depends on creatinine clearance.
What this interaction means in plain words
Entecavir and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Entecavir belongs to Anti Virals; Tacrolimus belongs to Miscellaneous.
Why it happens
Tacrolimus-induced nephrotoxicity may reduce renal clearance of entecavir.
What to do
Monitor serum creatinine regularly and adjust the entecavir dose or interval according to creatinine clearance; check tacrolimus trough levels as usual.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Entecavir
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Entecavir with Tacrolimus?
MediHelp rates the interaction as moderate. Entecavir and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus is nephrotoxic and can lower glomerular filtration, while entecavir relies on renal elimination. Declining kidney function may increase entecavir concentrations, and entecavir dosing depends on creatinine clearance.
How serious is the interaction between Entecavir and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine regularly and adjust the entecavir dose or interval according to creatinine clearance; check tacrolimus trough levels as usual.
What other medicines interact with Entecavir?
MediHelp also lists interactions of Entecavir with, for example, Alogliptin-metformin, Canagliflozin-metformin, Cidofovir. The full list is on the Entecavir page.
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