Drug interactions
Enzalutamide + Gefitinib
Severity: Moderate
Enzalutamide and Gefitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide strongly induces CYP3A4, which is the main metabolic route of gefitinib, so gefitinib exposure may drop substantially and may reduce antitumor efficacy.
What this interaction means in plain words
Enzalutamide and Gefitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Gefitinib belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4, increasing gefitinib clearance.
What to do
Consider an alternative to enzalutamide, or increase gefitinib to 500 mg daily as labeled for strong CYP3A4 inducers. Return to 250 mg daily about 7 days after stopping the inducer.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Gefitinib
Frequently asked questions
Can I take Enzalutamide with Gefitinib?
MediHelp rates the interaction as moderate. Enzalutamide and Gefitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide strongly induces CYP3A4, which is the main metabolic route of gefitinib, so gefitinib exposure may drop substantially and may reduce antitumor efficacy.
How serious is the interaction between Enzalutamide and Gefitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative to enzalutamide, or increase gefitinib to 500 mg daily as labeled for strong CYP3A4 inducers. Return to 250 mg daily about 7 days after stopping the inducer.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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