Drug interactions
Enzalutamide + Guanfacine
Severity: Moderate
Enzalutamide and Guanfacine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may considerably lower guanfacine plasma levels because guanfacine is cleared mainly by CYP3A4. This can lead to loss of blood pressure or ADHD symptom control.
What this interaction means in plain words
Enzalutamide and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Guanfacine belongs to Cardiovascular.
Why it happens
Enzalutamide induces CYP3A4, increasing guanfacine metabolism.
What to do
Monitor blood pressure or ADHD symptoms and increase the guanfacine dose as needed, for example consider doubling the extended-release dose. Reduce the dose again if enzalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Enzalutamide with Guanfacine?
MediHelp rates the interaction as moderate. Enzalutamide and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide may considerably lower guanfacine plasma levels because guanfacine is cleared mainly by CYP3A4. This can lead to loss of blood pressure or ADHD symptom control.
How serious is the interaction between Enzalutamide and Guanfacine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure or ADHD symptoms and increase the guanfacine dose as needed, for example consider doubling the extended-release dose. Reduce the dose again if enzalutamide is stopped.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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