Drug interactions
Enzalutamide + Hydrocodone
Severity: Moderate
Enzalutamide and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can substantially lower hydrocodone concentrations, causing loss of analgesia. After enzalutamide is stopped, the induction fades slowly and hydrocodone exposure may rise, risking respiratory depression.
What this interaction means in plain words
Enzalutamide and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Hydrocodone belongs to Musculoskeletal.
Why it happens
Strong CYP3A4 induction by enzalutamide increases hydrocodone metabolism.
What to do
Monitor pain control and titrate hydrocodone as needed, or choose an alternative analgesic. After stopping enzalutamide, reduce the hydrocodone dose and monitor for respiratory depression over the following weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Hydrocodone?
MediHelp rates the interaction as moderate. Enzalutamide and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can substantially lower hydrocodone concentrations, causing loss of analgesia. After enzalutamide is stopped, the induction fades slowly and hydrocodone exposure may rise, risking respiratory depression.
How serious is the interaction between Enzalutamide and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and titrate hydrocodone as needed, or choose an alternative analgesic. After stopping enzalutamide, reduce the hydrocodone dose and monitor for respiratory depression over the following weeks.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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