Drug interactions
Enzalutamide + Naldemedine
Severity: Moderate
Enzalutamide and Naldemedine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inducers reduce naldemedine exposure and may weaken its relief of opioid-induced constipation.
What this interaction means in plain words
Enzalutamide and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Enzalutamide induces CYP3A4, increasing naldemedine clearance.
What to do
Avoid combining where possible and use another laxative strategy. Monitor bowel function if used together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Enzalutamide with Naldemedine?
MediHelp rates the interaction as moderate. Enzalutamide and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A4 inducers reduce naldemedine exposure and may weaken its relief of opioid-induced constipation.
How serious is the interaction between Enzalutamide and Naldemedine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and use another laxative strategy. Monitor bowel function if used together.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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