Drug interactions
Enzalutamide + Naloxegol
Severity: Moderate
Enzalutamide and Naloxegol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naloxegol is a CYP3A4 substrate, and strong inducers markedly reduce its levels, potentially resulting in loss of efficacy against opioid-induced constipation. This is a loss of effect rather than a safety hazard.
What this interaction means in plain words
Enzalutamide and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Enzalutamide induces CYP3A4 and increases naloxegol metabolism.
What to do
Avoid the combination and use an alternative laxative approach. Monitor bowel function if naloxegol is continued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Enzalutamide with Naloxegol?
MediHelp rates the interaction as moderate. Enzalutamide and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naloxegol is a CYP3A4 substrate, and strong inducers markedly reduce its levels, potentially resulting in loss of efficacy against opioid-induced constipation. This is a loss of effect rather than a safety hazard.
How serious is the interaction between Enzalutamide and Naloxegol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative laxative approach. Monitor bowel function if naloxegol is continued.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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