Drug interactions
Enzalutamide + Oliceridine
Severity: Moderate
Enzalutamide and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may reduce oliceridine exposure, leading to inadequate analgesia or withdrawal in opioid-dependent patients. When the inducer is stopped, oliceridine levels may rise and cause respiratory depression.
What this interaction means in plain words
Enzalutamide and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Oliceridine belongs to Musculoskeletal.
Why it happens
Enzalutamide induces CYP3A4, which is a major clearance pathway for oliceridine.
What to do
Titrate oliceridine to effect and monitor for withdrawal or poor analgesia. After stopping enzalutamide, reduce the dose and monitor for sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Enzalutamide with Oliceridine?
MediHelp rates the interaction as moderate. Enzalutamide and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide may reduce oliceridine exposure, leading to inadequate analgesia or withdrawal in opioid-dependent patients. When the inducer is stopped, oliceridine levels may rise and cause respiratory depression.
How serious is the interaction between Enzalutamide and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate oliceridine to effect and monitor for withdrawal or poor analgesia. After stopping enzalutamide, reduce the dose and monitor for sedation and respiratory depression.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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