Drug interactions
Enzalutamide + Primaquine
Severity: Moderate
Enzalutamide and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and may lower primaquine exposure. Reduced exposure could weaken efficacy against liver-stage malaria and increase the risk of relapse or treatment failure.
What this interaction means in plain words
Enzalutamide and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Primaquine belongs to Anti Parasitic.
Why it happens
Enzalutamide induction of CYP3A4 (and other enzymes) increases the metabolism of primaquine; the clinical contribution of CYP3A4 to primaquine clearance is uncertain, as other pathways such as MAO-A and CYP2D6 also contribute.
What to do
Where possible, avoid the combination or monitor the patient for relapse after radical cure. Consider an alternative antimalarial strategy if the clinical response is doubtful.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Primaquine?
MediHelp rates the interaction as moderate. Enzalutamide and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and may lower primaquine exposure. Reduced exposure could weaken efficacy against liver-stage malaria and increase the risk of relapse or treatment failure.
How serious is the interaction between Enzalutamide and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, avoid the combination or monitor the patient for relapse after radical cure. Consider an alternative antimalarial strategy if the clinical response is doubtful.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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