Drug interactions
Enzalutamide + Quetiapine
Severity: Major
Enzalutamide and Quetiapine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can substantially lower quetiapine concentrations. This may lead to loss of antipsychotic or mood-stabilizing effect and relapse.
What this interaction means in plain words
Enzalutamide and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Quetiapine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by enzalutamide increases quetiapine metabolism.
What to do
Monitor for loss of efficacy and titrate quetiapine upward as required, which may be a large increase. If enzalutamide is stopped, reduce quetiapine again over the following weeks to avoid toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Quetiapine?
MediHelp rates the interaction as major. Enzalutamide and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide is a strong CYP3A4 inducer and can substantially lower quetiapine concentrations. This may lead to loss of antipsychotic or mood-stabilizing effect and relapse.
How serious is the interaction between Enzalutamide and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy and titrate quetiapine upward as required, which may be a large increase. If enzalutamide is stopped, reduce quetiapine again over the following weeks to avoid toxicity.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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