Drug interactions
Enzalutamide + Quizartinib
Severity: Major
Enzalutamide and Quizartinib: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and quizartinib is cleared mainly by CYP3A4. Coadministration can lower quizartinib exposure and may reduce its antileukemic effect.
What this interaction means in plain words
Enzalutamide and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Quizartinib belongs to Oncology.
Why it happens
Induction of CYP3A4 by enzalutamide increases quizartinib metabolism and lowers its plasma concentrations.
What to do
Avoid combining with strong CYP3A inducers where possible and consider an alternative anticancer or antiandrogen therapy. If unavoidable, monitor leukemia response and ECG/QT closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Enzalutamide with Quizartinib?
MediHelp rates the interaction as major. Enzalutamide and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide is a strong CYP3A4 inducer and quizartinib is cleared mainly by CYP3A4. Coadministration can lower quizartinib exposure and may reduce its antileukemic effect.
How serious is the interaction between Enzalutamide and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with strong CYP3A inducers where possible and consider an alternative anticancer or antiandrogen therapy. If unavoidable, monitor leukemia response and ECG/QT closely.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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