Drug interactions
Enzalutamide + Saxagliptin-metformin
Severity: Moderate
Enzalutamide and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and may lower saxagliptin exposure along with its active metabolite. This could reduce glycemic control, although the effect on metformin is not expected to be significant.
What this interaction means in plain words
Enzalutamide and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Induction of CYP3A4/5 by enzalutamide increases saxagliptin metabolism.
What to do
Monitor blood glucose and HbA1c after starting enzalutamide and adjust antidiabetic therapy if control worsens. Consider an alternative agent if glycemic control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Enzalutamide and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and may lower saxagliptin exposure along with its active metabolite. This could reduce glycemic control, although the effect on metformin is not expected to be significant.
How serious is the interaction between Enzalutamide and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting enzalutamide and adjust antidiabetic therapy if control worsens. Consider an alternative agent if glycemic control is lost.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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