Drug interactions
Enzalutamide + Sufentanil
Severity: Moderate
Enzalutamide and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may reduce sufentanil exposure, leading to weaker analgesia. After enzalutamide is stopped, sufentanil levels may rise and cause respiratory depression.
What this interaction means in plain words
Enzalutamide and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Sufentanil belongs to Musculoskeletal.
Why it happens
Enzalutamide induces CYP3A4, the main route of sufentanil metabolism.
What to do
Titrate sufentanil to clinical effect and watch for inadequate analgesia. Monitor for respiratory depression after enzalutamide is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Enzalutamide with Sufentanil?
MediHelp rates the interaction as moderate. Enzalutamide and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide may reduce sufentanil exposure, leading to weaker analgesia. After enzalutamide is stopped, sufentanil levels may rise and cause respiratory depression.
How serious is the interaction between Enzalutamide and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sufentanil to clinical effect and watch for inadequate analgesia. Monitor for respiratory depression after enzalutamide is withdrawn.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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