Drug interactions
Enzalutamide + Verapamil
Severity: Moderate
Enzalutamide and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can substantially reduce exposure to CYP3A4 substrates such as verapamil. This may lead to loss of blood pressure or heart rate control.
What this interaction means in plain words
Enzalutamide and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Verapamil belongs to Cardiovascular.
Why it happens
Enzalutamide induces CYP3A4, increasing verapamil metabolism and lowering its concentrations.
What to do
Monitor blood pressure and heart rate and titrate verapamil upward as needed. Reassess the dose when enzalutamide is stopped, as the induction wanes over weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Verapamil?
MediHelp rates the interaction as moderate. Enzalutamide and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can substantially reduce exposure to CYP3A4 substrates such as verapamil. This may lead to loss of blood pressure or heart rate control.
How serious is the interaction between Enzalutamide and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and titrate verapamil upward as needed. Reassess the dose when enzalutamide is stopped, as the induction wanes over weeks.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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