Drug interactions
Enzalutamide + Vinblastine
Severity: Moderate
Enzalutamide and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may lower vinblastine concentrations by inducing CYP3A4, which could reduce chemotherapy effectiveness. The magnitude has not been well characterized clinically.
What this interaction means in plain words
Enzalutamide and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Vinblastine belongs to Oncology.
Why it happens
CYP3A4 induction increases hepatic metabolism of vinblastine.
What to do
Monitor for reduced antineoplastic response and consider an alternative to enzalutamide or regimen adjustment if loss of efficacy is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Vinblastine
Frequently asked questions
Can I take Enzalutamide with Vinblastine?
MediHelp rates the interaction as moderate. Enzalutamide and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide may lower vinblastine concentrations by inducing CYP3A4, which could reduce chemotherapy effectiveness. The magnitude has not been well characterized clinically.
How serious is the interaction between Enzalutamide and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antineoplastic response and consider an alternative to enzalutamide or regimen adjustment if loss of efficacy is suspected.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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