Drug interactions
Enzalutamide + Voclosporin
Severity: Major
Enzalutamide and Voclosporin: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a CYP3A4 substrate and enzalutamide strongly induces this enzyme. Reduced voclosporin exposure may lead to loss of efficacy in lupus nephritis.
What this interaction means in plain words
Enzalutamide and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Voclosporin belongs to Miscellaneous.
Why it happens
Enzalutamide induces CYP3A4, increasing the metabolism of voclosporin.
What to do
Avoid concomitant use, since voclosporin labeling advises against strong CYP3A4 inducers. If it cannot be avoided, monitor renal response and proteinuria closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Enzalutamide with Voclosporin?
MediHelp rates the interaction as major. Enzalutamide and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin is a CYP3A4 substrate and enzalutamide strongly induces this enzyme. Reduced voclosporin exposure may lead to loss of efficacy in lupus nephritis.
How serious is the interaction between Enzalutamide and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use, since voclosporin labeling advises against strong CYP3A4 inducers. If it cannot be avoided, monitor renal response and proteinuria closely.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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