Drug interactions
Enzalutamide + Vonoprazan
Severity: Moderate
Enzalutamide and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan is metabolized mainly by CYP3A4, and enzalutamide strongly induces this enzyme. Lower vonoprazan levels may result in inadequate acid suppression and poorer healing or symptom control.
What this interaction means in plain words
Enzalutamide and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Enzalutamide induces CYP3A4, reducing vonoprazan exposure.
What to do
Avoid the combination if possible and consider a different acid suppressant. If used together, monitor for symptom recurrence or treatment failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Enzalutamide and Vonoprazan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Enzalutamide with Vonoprazan?
MediHelp rates the interaction as moderate. Enzalutamide and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan is metabolized mainly by CYP3A4, and enzalutamide strongly induces this enzyme. Lower vonoprazan levels may result in inadequate acid suppression and poorer healing or symptom control.
How serious is the interaction between Enzalutamide and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and consider a different acid suppressant. If used together, monitor for symptom recurrence or treatment failure.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
