Drug interactions
Epcoritamab + Fluvoxamine
Severity: Moderate
Epcoritamab and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab induces cytokine release that can transiently suppress CYP enzymes, potentially increasing exposure to fluvoxamine, a CYP1A2 and CYP2D6 substrate. The effect is greatest around the first doses and during CRS, but fluvoxamine has a wide therapeutic margin.
What this interaction means in plain words
Epcoritamab and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Fluvoxamine belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP enzymes may reduce fluvoxamine clearance.
What to do
Monitor for fluvoxamine adverse effects during the initial epcoritamab dosing and CRS, and adjust the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Fluvoxamine?
MediHelp rates the interaction as moderate. Epcoritamab and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab induces cytokine release that can transiently suppress CYP enzymes, potentially increasing exposure to fluvoxamine, a CYP1A2 and CYP2D6 substrate. The effect is greatest around the first doses and during CRS, but fluvoxamine has a wide therapeutic margin.
How serious is the interaction between Epcoritamab and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for fluvoxamine adverse effects during the initial epcoritamab dosing and CRS, and adjust the dose if needed.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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