Drug interactions
Epcoritamab + Midazolam
Severity: Moderate
Epcoritamab and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab causes cytokine release that can temporarily suppress CYP enzyme activity, raising exposure to CYP3A4 substrates such as midazolam. This may lead to deeper or longer sedation, mainly around the first doses.
What this interaction means in plain words
Epcoritamab and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Midazolam belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP3A4 activity.
What to do
Monitor for oversedation after epcoritamab initiation and during CRS, and reduce the midazolam dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Midazolam?
MediHelp rates the interaction as moderate. Epcoritamab and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab causes cytokine release that can temporarily suppress CYP enzyme activity, raising exposure to CYP3A4 substrates such as midazolam. This may lead to deeper or longer sedation, mainly around the first doses.
How serious is the interaction between Epcoritamab and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation after epcoritamab initiation and during CRS, and reduce the midazolam dose if needed.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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