Drug interactions
Epcoritamab + Sirolimus
Severity: Moderate
Epcoritamab and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab triggers cytokine release, which can transiently suppress CYP3A activity. Sirolimus exposure may increase, particularly around the step-up doses and during cytokine release syndrome.
What this interaction means in plain words
Epcoritamab and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Cytokine-mediated suppression of CYP3A4 expression reduces sirolimus clearance.
What to do
Monitor sirolimus trough levels and toxicity during the first weeks of epcoritamab and during cytokine release syndrome; reduce the sirolimus dose if concentrations rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Sirolimus?
MediHelp rates the interaction as moderate. Epcoritamab and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab triggers cytokine release, which can transiently suppress CYP3A activity. Sirolimus exposure may increase, particularly around the step-up doses and during cytokine release syndrome.
How serious is the interaction between Epcoritamab and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels and toxicity during the first weeks of epcoritamab and during cytokine release syndrome; reduce the sirolimus dose if concentrations rise.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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