Drug interactions
Epcoritamab + Tacrolimus
Severity: Moderate
Epcoritamab and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release caused by epcoritamab can temporarily suppress CYP3A4 and increase tacrolimus exposure. Tacrolimus toxicity may result during the period of cytokine release.
What this interaction means in plain words
Epcoritamab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Cytokine-mediated suppression of CYP3A4 activity decreases tacrolimus clearance.
What to do
Monitor tacrolimus trough levels and renal function during the first cycles and during CRS, adjusting the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Tacrolimus?
MediHelp rates the interaction as moderate. Epcoritamab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release caused by epcoritamab can temporarily suppress CYP3A4 and increase tacrolimus exposure. Tacrolimus toxicity may result during the period of cytokine release.
How serious is the interaction between Epcoritamab and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function during the first cycles and during CRS, adjusting the dose accordingly.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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