Drug interactions
Epcoritamab + Tizanidine
Severity: Moderate
Epcoritamab and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab releases cytokines, which can temporarily suppress hepatic CYP enzymes including CYP1A2, the main route of tizanidine clearance. This may raise tizanidine levels and increase hypotension, bradycardia and sedation, especially around cytokine release syndrome.
What this interaction means in plain words
Epcoritamab and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Epcoritamab belongs to Oncology; Tizanidine belongs to Musculoskeletal.
Why it happens
Cytokine-mediated suppression of CYP1A2 reduces tizanidine metabolism.
What to do
Monitor blood pressure, heart rate and sedation after the first doses and during cytokine release syndrome. Reduce or hold tizanidine if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Tizanidine?
MediHelp rates the interaction as moderate. Epcoritamab and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab releases cytokines, which can temporarily suppress hepatic CYP enzymes including CYP1A2, the main route of tizanidine clearance. This may raise tizanidine levels and increase hypotension, bradycardia and sedation, especially around cytokine release syndrome.
How serious is the interaction between Epcoritamab and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation after the first doses and during cytokine release syndrome. Reduce or hold tizanidine if adverse effects appear.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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