Drug interactions
Ephedrine + Metolazone
Severity: Minor
Ephedrine and Metolazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ephedrine can shift potassium into cells, and with metolazone's renal potassium loss may add to hypokalemia. Ephedrine may also oppose the antihypertensive effect of metolazone.
What this interaction means in plain words
Ephedrine and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ephedrine belongs to Cardiovascular; Metolazone belongs to Cardiovascular.
Why it happens
Beta-adrenergic potassium shift plus diuretic kaliuresis; pressor effect antagonizes antihypertensive action.
What to do
Monitor serum potassium and blood pressure if ephedrine is used repeatedly or at high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metolazone
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ephedrine with Metolazone?
MediHelp rates the interaction as minor. Ephedrine and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ephedrine can shift potassium into cells, and with metolazone's renal potassium loss may add to hypokalemia. Ephedrine may also oppose the antihypertensive effect of metolazone.
How serious is the interaction between Ephedrine and Metolazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure if ephedrine is used repeatedly or at high doses.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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