Drug interactions
Ephedrine + Modafinil
Severity: Moderate
Ephedrine and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ephedrine is a sympathomimetic and modafinil is a CNS stimulant, so combined use may cause additive increases in blood pressure and heart rate, with insomnia or anxiety. Risk is greater with cardiovascular disease.
What this interaction means in plain words
Ephedrine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ephedrine belongs to Cardiovascular; Modafinil belongs to Central Nervous System.
Why it happens
Additive sympathomimetic and CNS stimulant effects.
What to do
Monitor blood pressure and heart rate and avoid combination in uncontrolled hypertension or arrhythmias. Reduce doses if palpitations or hypertension occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ephedrine with Modafinil?
MediHelp rates the interaction as moderate. Ephedrine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ephedrine is a sympathomimetic and modafinil is a CNS stimulant, so combined use may cause additive increases in blood pressure and heart rate, with insomnia or anxiety. Risk is greater with cardiovascular disease.
How serious is the interaction between Ephedrine and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and avoid combination in uncontrolled hypertension or arrhythmias. Reduce doses if palpitations or hypertension occur.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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