Drug interactions
Ephedrine + Sotalol
Severity: Moderate
Ephedrine and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol opposes the beta-mediated effects of ephedrine, reducing its cardiac and bronchodilator effects. Unopposed alpha stimulation may produce hypertension and reflex bradycardia.
What this interaction means in plain words
Ephedrine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ephedrine belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism between a nonselective beta-blocker and a mixed sympathomimetic.
What to do
Monitor blood pressure and heart rate and avoid routine use of ephedrine in patients on sotalol, particularly asthmatics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ephedrine with Sotalol?
MediHelp rates the interaction as moderate. Ephedrine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotalol opposes the beta-mediated effects of ephedrine, reducing its cardiac and bronchodilator effects. Unopposed alpha stimulation may produce hypertension and reflex bradycardia.
How serious is the interaction between Ephedrine and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and avoid routine use of ephedrine in patients on sotalol, particularly asthmatics.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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