Drug interactions
Ephedrine + Trazodone
Severity: Moderate
Ephedrine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ephedrine releases norepinephrine and stimulates adrenergic receptors, while trazodone blocks alpha-1 receptors and affects serotonin pathways. The pressor response to ephedrine may therefore be altered, and hemodynamic effects are less predictable.
What this interaction means in plain words
Ephedrine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ephedrine belongs to Cardiovascular; Trazodone belongs to Central Nervous System.
Why it happens
Pharmacodynamic interaction at adrenergic receptors and monoamine pathways; the extent is not well established.
What to do
Monitor blood pressure and heart rate and titrate ephedrine to effect. Be prepared to adjust doses if the response is blunted or exaggerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Ephedrine with Trazodone?
MediHelp rates the interaction as moderate. Ephedrine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ephedrine releases norepinephrine and stimulates adrenergic receptors, while trazodone blocks alpha-1 receptors and affects serotonin pathways. The pressor response to ephedrine may therefore be altered, and hemodynamic effects are less predictable.
How serious is the interaction between Ephedrine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and titrate ephedrine to effect. Be prepared to adjust doses if the response is blunted or exaggerated.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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