Drug interactions
Eplerenone + Rucaparib
Severity: Minor
Eplerenone and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 weakly, and eplerenone is a CYP3A4 substrate. Eplerenone exposure may increase modestly, raising the risk of hyperkalemia.
What this interaction means in plain words
Eplerenone and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eplerenone belongs to Cardiovascular; Rucaparib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 by rucaparib, reducing eplerenone metabolism.
What to do
Monitor serum potassium and blood pressure, and adjust the eplerenone dose if clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Eplerenone with Rucaparib?
MediHelp rates the interaction as minor. Eplerenone and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP3A4 weakly, and eplerenone is a CYP3A4 substrate. Eplerenone exposure may increase modestly, raising the risk of hyperkalemia.
How serious is the interaction between Eplerenone and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, and adjust the eplerenone dose if clinically indicated.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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