Drug interactions
Eplerenone + Stiripentol
Severity: Moderate
Eplerenone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol can both inhibit and induce CYP3A4, so the effect on eplerenone exposure is unpredictable. Levels may rise or fall, with a risk of either hyperkalemia or loss of efficacy.
What this interaction means in plain words
Eplerenone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eplerenone belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol altering eplerenone metabolism.
What to do
Monitor blood pressure and serum potassium after starting or stopping stiripentol, and adjust the eplerenone dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Eplerenone with Stiripentol?
MediHelp rates the interaction as moderate. Eplerenone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol can both inhibit and induce CYP3A4, so the effect on eplerenone exposure is unpredictable. Levels may rise or fall, with a risk of either hyperkalemia or loss of efficacy.
How serious is the interaction between Eplerenone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium after starting or stopping stiripentol, and adjust the eplerenone dose accordingly.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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