Drug interactions
Erdafitinib + Silodosin
Severity: Moderate
Erdafitinib and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein and may raise exposure to P-gp substrates such as silodosin. Increased silodosin levels may cause more hypotension and dizziness.
What this interaction means in plain words
Erdafitinib and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erdafitinib belongs to Oncology; Silodosin belongs to Genitourinary.
Why it happens
Erdafitinib inhibits intestinal and cellular P-gp efflux, increasing silodosin absorption and reducing its clearance.
What to do
Monitor blood pressure and orthostatic symptoms when starting erdafitinib. Separating dosing by about 6 hours is advised in erdafitinib labeling for narrow-therapeutic-index P-gp substrates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Erdafitinib with Silodosin?
MediHelp rates the interaction as moderate. Erdafitinib and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein and may raise exposure to P-gp substrates such as silodosin. Increased silodosin levels may cause more hypotension and dizziness.
How serious is the interaction between Erdafitinib and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting erdafitinib. Separating dosing by about 6 hours is advised in erdafitinib labeling for narrow-therapeutic-index P-gp substrates.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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