Drug interactions
Ergotamine + Fluphenazine
Severity: Moderate
Ergotamine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine causes vasoconstriction and has serotonergic activity, while fluphenazine causes sedation and can alter dopamine and serotonin signaling. Reports of serotonin syndrome or neuroleptic malignant syndrome are rare, and the main concern is theoretical.
What this interaction means in plain words
Ergotamine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Fluphenazine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic and dopaminergic effects; the mechanism is not firmly established.
What to do
Monitor for mental status change, hyperthermia, rigidity and autonomic instability when the combination is used. Limit ergotamine to the lowest effective dose and stop it if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Fluphenazine?
MediHelp rates the interaction as moderate. Ergotamine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergotamine causes vasoconstriction and has serotonergic activity, while fluphenazine causes sedation and can alter dopamine and serotonin signaling. Reports of serotonin syndrome or neuroleptic malignant syndrome are rare, and the main concern is theoretical.
How serious is the interaction between Ergotamine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, hyperthermia, rigidity and autonomic instability when the combination is used. Limit ergotamine to the lowest effective dose and stop it if toxicity is suspected.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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