Drug interactions
Ergotamine + Haloperidol
Severity: Moderate
Ergotamine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on dopaminergic and serotonergic pathways, and combining them theoretically raises the risk of serotonin toxicity or neuroleptic malignant syndrome. Reports of this specific pairing are scarce, and the concern is mainly extrapolated from class effects.
What this interaction means in plain words
Ergotamine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Additive serotonergic and dopaminergic modulation; the exact mechanism for this pair is not firmly established.
What to do
Monitor for mental status change, autonomic instability, hyperthermia, rigidity and neuromuscular hyperactivity. Stop one or both agents if signs of serotonin toxicity or neuroleptic malignant syndrome appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Haloperidol?
MediHelp rates the interaction as moderate. Ergotamine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on dopaminergic and serotonergic pathways, and combining them theoretically raises the risk of serotonin toxicity or neuroleptic malignant syndrome. Reports of this specific pairing are scarce, and the concern is mainly extrapolated from class effects.
How serious is the interaction between Ergotamine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, autonomic instability, hyperthermia, rigidity and neuromuscular hyperactivity. Stop one or both agents if signs of serotonin toxicity or neuroleptic malignant syndrome appear.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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