Drug interactions
Ergotamine + Iloperidone
Severity: Moderate
Ergotamine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak time-dependent CYP3A4 inhibitor and may raise ergotamine levels, increasing the risk of vasospasm. Additive serotonergic and dopaminergic effects are also theoretically possible.
What this interaction means in plain words
Ergotamine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by iloperidone reduces ergotamine metabolism, with possible additive serotonergic activity.
What to do
Monitor for ergotism and for serotonin toxicity features such as agitation, tremor and hyperthermia. Use the lowest effective ergotamine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Ergotamine with Iloperidone?
MediHelp rates the interaction as moderate. Ergotamine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is a weak time-dependent CYP3A4 inhibitor and may raise ergotamine levels, increasing the risk of vasospasm. Additive serotonergic and dopaminergic effects are also theoretically possible.
How serious is the interaction between Ergotamine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ergotism and for serotonin toxicity features such as agitation, tremor and hyperthermia. Use the lowest effective ergotamine dose.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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