Drug interactions
Ergotamine + Lomitapide
Severity: Moderate
Ergotamine and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine is a weak CYP3A4 inhibitor and may increase lomitapide exposure. Raised lomitapide levels increase the risk of hepatotoxicity and gastrointestinal adverse effects.
What this interaction means in plain words
Ergotamine and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Lomitapide belongs to Cardiovascular.
Why it happens
Ergotamine inhibits CYP3A4, reducing lomitapide metabolism.
What to do
Monitor liver enzymes and gastrointestinal tolerability. Keep the lomitapide dose within the labeled limit for weak CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Ergotamine with Lomitapide?
MediHelp rates the interaction as moderate. Ergotamine and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergotamine is a weak CYP3A4 inhibitor and may increase lomitapide exposure. Raised lomitapide levels increase the risk of hepatotoxicity and gastrointestinal adverse effects.
How serious is the interaction between Ergotamine and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and gastrointestinal tolerability. Keep the lomitapide dose within the labeled limit for weak CYP3A4 inhibitors.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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