Drug interactions
Ergotamine + Lurasidone
Severity: Moderate
Ergotamine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine is metabolized by CYP3A4 and causes vasoconstriction. Lurasidone does not inhibit CYP3A4, so the main concern is pharmacodynamic: antagonism of dopamine and serotonin signaling and additive alpha-adrenergic effects. Serotonin syndrome is theoretically possible but rarely reported.
What this interaction means in plain words
Ergotamine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic overlap at serotonergic and adrenergic receptors; no pharmacokinetic interaction is established.
What to do
Monitor for signs of serotonin toxicity and for blood pressure changes. Avoid concurrent CYP3A4 inhibitors with ergotamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Lurasidone?
MediHelp rates the interaction as moderate. Ergotamine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergotamine is metabolized by CYP3A4 and causes vasoconstriction. Lurasidone does not inhibit CYP3A4, so the main concern is pharmacodynamic: antagonism of dopamine and serotonin signaling and additive alpha-adrenergic effects. Serotonin syndrome is theoretically possible but rarely reported.
How serious is the interaction between Ergotamine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity and for blood pressure changes. Avoid concurrent CYP3A4 inhibitors with ergotamine.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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