Drug interactions
Ergotamine + Midazolam
Severity: Minor
Ergotamine and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine is a CYP3A4 substrate and is not known to inhibit midazolam metabolism meaningfully. The clinically important CYP3A4 interactions with ergotamine involve potent inhibitors, not midazolam.
What this interaction means in plain words
Ergotamine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ergotamine belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
No established mechanism; both drugs are CYP3A4 substrates with possible minor competition.
What to do
No adjustment is needed for midazolam; titrate to effect with standard monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Midazolam?
MediHelp rates the interaction as minor. Ergotamine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ergotamine is a CYP3A4 substrate and is not known to inhibit midazolam metabolism meaningfully. The clinically important CYP3A4 interactions with ergotamine involve potent inhibitors, not midazolam.
How serious is the interaction between Ergotamine and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed for midazolam; titrate to effect with standard monitoring.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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