Drug interactions
Ergotamine + Pentazocine
Severity: Minor
Ergotamine and Pentazocine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The legacy concern is serotonergic overlap, but ergotamine acts mainly as a vasoconstrictor via serotonin receptor agonism and there is little evidence of a clinically significant interaction with pentazocine. Theoretical additive serotonergic effects are possible.
What this interaction means in plain words
Ergotamine and Pentazocine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ergotamine belongs to Central Nervous System; Pentazocine belongs to Musculoskeletal.
Why it happens
Theoretical additive serotonergic activity; not well established.
What to do
Counsel the patient to report agitation, tremor, sweating or fever, and stop treatment if serotonin toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Pentazocine?
MediHelp rates the interaction as minor. Ergotamine and Pentazocine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The legacy concern is serotonergic overlap, but ergotamine acts mainly as a vasoconstrictor via serotonin receptor agonism and there is little evidence of a clinically significant interaction with pentazocine. Theoretical additive serotonergic effects are possible.
How serious is the interaction between Ergotamine and Pentazocine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, sweating or fever, and stop treatment if serotonin toxicity is suspected.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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