Drug interactions
Ergotamine + Perphenazine
Severity: Moderate
Ergotamine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine is a vasoconstrictor with serotonergic activity, and its combination with perphenazine has been flagged for possible serotonergic toxicity and additive dopaminergic effects. Evidence is limited, but ergotamine toxicity from other interacting drugs can cause severe ischemia. Perphenazine is not a strong CYP3A4 inhibitor, so the main concern is pharmacodynamic.
What this interaction means in plain words
Ergotamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic and dopamine-modulating effects; the mechanism is not firmly established.
What to do
Monitor for serotonin toxicity, neuroleptic malignant syndrome and signs of peripheral ischemia such as cold or numb extremities. Keep ergotamine doses within label limits and stop it if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Ergotamine with Perphenazine?
MediHelp rates the interaction as moderate. Ergotamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergotamine is a vasoconstrictor with serotonergic activity, and its combination with perphenazine has been flagged for possible serotonergic toxicity and additive dopaminergic effects. Evidence is limited, but ergotamine toxicity from other interacting drugs can cause severe ischemia. Perphenazine is not a strong CYP3A4 inhibitor, so the main concern is pharmacodynamic.
How serious is the interaction between Ergotamine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity, neuroleptic malignant syndrome and signs of peripheral ischemia such as cold or numb extremities. Keep ergotamine doses within label limits and stop it if symptoms appear.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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