Drug interactions
Ergotamine + Phentermine
Severity: Major
Ergotamine and Phentermine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine is a sympathomimetic that raises blood pressure and heart rate. With ergotamine, additive vasoconstriction may lead to hypertension and peripheral or cerebral ischemia.
What this interaction means in plain words
Ergotamine and Phentermine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ergotamine belongs to Central Nervous System; Phentermine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic vasoconstrictor and pressor effects.
What to do
Avoid combining; choose an alternative migraine regimen while on phentermine. Monitor blood pressure and watch for ischemic symptoms if exposure occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Ergotamine with Phentermine?
MediHelp rates the interaction as major. Ergotamine and Phentermine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phentermine is a sympathomimetic that raises blood pressure and heart rate. With ergotamine, additive vasoconstriction may lead to hypertension and peripheral or cerebral ischemia.
How serious is the interaction between Ergotamine and Phentermine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; choose an alternative migraine regimen while on phentermine. Monitor blood pressure and watch for ischemic symptoms if exposure occurs.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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