Drug interactions
Ergotamine + Talquetamab
Severity: Moderate
Ergotamine and Talquetamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release syndrome caused by talquetamab can suppress CYP enzymes, potentially raising ergotamine levels. This increases the risk of vasospasm and ischemia, especially during step-up dosing.
What this interaction means in plain words
Ergotamine and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Talquetamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 reduces ergotamine metabolism.
What to do
Monitor for ergotism signs during step-up dosing and for several days after any cytokine release syndrome. Consider holding ergotamine during that period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Ergotamine with Talquetamab?
MediHelp rates the interaction as moderate. Ergotamine and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release syndrome caused by talquetamab can suppress CYP enzymes, potentially raising ergotamine levels. This increases the risk of vasospasm and ischemia, especially during step-up dosing.
How serious is the interaction between Ergotamine and Talquetamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ergotism signs during step-up dosing and for several days after any cytokine release syndrome. Consider holding ergotamine during that period.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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