Drug interactions
Ergotamine + Tazemetostat
Severity: Minor
Ergotamine and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak to moderate CYP3A inducer and may lower ergotamine exposure, reducing efficacy. Tazemetostat is a CYP3A substrate, but ergotamine is not a meaningful inhibitor of it, so the reverse effect is unlikely to be significant.
What this interaction means in plain words
Ergotamine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ergotamine belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat induces CYP3A4, increasing ergotamine clearance.
What to do
Monitor for reduced migraine control and adjust the ergotamine regimen if needed. No tazemetostat dose change is typically required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ergotamine and Tazemetostat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Ergotamine with Tazemetostat?
MediHelp rates the interaction as minor. Ergotamine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak to moderate CYP3A inducer and may lower ergotamine exposure, reducing efficacy. Tazemetostat is a CYP3A substrate, but ergotamine is not a meaningful inhibitor of it, so the reverse effect is unlikely to be significant.
How serious is the interaction between Ergotamine and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced migraine control and adjust the ergotamine regimen if needed. No tazemetostat dose change is typically required.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
