Drug interactions
Ergotamine + Trofinetide
Severity: Moderate
Ergotamine and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide weakly inhibits CYP3A4 and may raise ergotamine levels. Because small increases in ergotamine can cause vasospasm and ischemia, the combination warrants attention.
What this interaction means in plain words
Ergotamine and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergotamine belongs to Central Nervous System; Trofinetide belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by trofinetide reduces ergotamine clearance.
What to do
Monitor for ergotism signs such as cold extremities, paresthesia and severe headache. Use the lowest effective ergotamine dose or choose an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Trofinetide
Frequently asked questions
Can I take Ergotamine with Trofinetide?
MediHelp rates the interaction as moderate. Ergotamine and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide weakly inhibits CYP3A4 and may raise ergotamine levels. Because small increases in ergotamine can cause vasospasm and ischemia, the combination warrants attention.
How serious is the interaction between Ergotamine and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ergotism signs such as cold extremities, paresthesia and severe headache. Use the lowest effective ergotamine dose or choose an alternative.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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