Drug interactions
Ertugliflozin + Glyburide-metformin
Severity: Moderate
Ertugliflozin and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining ertugliflozin with glyburide increases glucose-lowering effect and the risk of hypoglycemia. Ertugliflozin also causes volume depletion, which may affect renal function and metformin handling.
What this interaction means in plain words
Ertugliflozin and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Glyburide-metformin belongs to Endocrine.
Why it happens
Additive glucose lowering through insulin secretion by sulfonylurea and insulin-independent urinary glucose excretion from SGLT2 inhibition.
What to do
Consider reducing the glyburide dose when starting ertugliflozin and monitor blood glucose. Check renal function and hydration status periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
Frequently asked questions
Can I take Ertugliflozin with Glyburide-metformin?
MediHelp rates the interaction as moderate. Ertugliflozin and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining ertugliflozin with glyburide increases glucose-lowering effect and the risk of hypoglycemia. Ertugliflozin also causes volume depletion, which may affect renal function and metformin handling.
How serious is the interaction between Ertugliflozin and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose when starting ertugliflozin and monitor blood glucose. Check renal function and hydration status periodically.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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