Drug interactions
Ertugliflozin + Ifosfamide
Severity: Moderate
Ertugliflozin and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide can cause tubular nephrotoxicity, while ertugliflozin can cause volume depletion and acute kidney injury. Together they may increase the risk of renal impairment and dehydration, and the glucose-lowering effect of ertugliflozin drops with reduced renal function.
What this interaction means in plain words
Ertugliflozin and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Ifosfamide belongs to Oncology.
Why it happens
Additive renal risk from ifosfamide tubular toxicity and SGLT2-inhibitor volume depletion.
What to do
Monitor renal function and hydration status, and hold ertugliflozin during acute illness, vomiting or reduced intake. Watch for ketoacidosis in patients on chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
Frequently asked questions
Can I take Ertugliflozin with Ifosfamide?
MediHelp rates the interaction as moderate. Ertugliflozin and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide can cause tubular nephrotoxicity, while ertugliflozin can cause volume depletion and acute kidney injury. Together they may increase the risk of renal impairment and dehydration, and the glucose-lowering effect of ertugliflozin drops with reduced renal function.
How serious is the interaction between Ertugliflozin and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and hydration status, and hold ertugliflozin during acute illness, vomiting or reduced intake. Watch for ketoacidosis in patients on chemotherapy.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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