Drug interactions
Ertugliflozin + Insulin degludec-liraglutide
Severity: Moderate
Ertugliflozin and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ertugliflozin lowers glucose independently of insulin, so combining it with insulin degludec and liraglutide increases the chance of hypoglycemia. Volume depletion and ketoacidosis are additional concerns with this combination.
What this interaction means in plain words
Ertugliflozin and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Additive glucose lowering from SGLT2 inhibition combined with insulin and GLP-1 receptor agonist actions.
What to do
Consider lowering the insulin dose when ertugliflozin is added and monitor blood glucose closely. Check for ketosis if the patient becomes unwell.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
Frequently asked questions
Can I take Ertugliflozin with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Ertugliflozin and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ertugliflozin lowers glucose independently of insulin, so combining it with insulin degludec and liraglutide increases the chance of hypoglycemia. Volume depletion and ketoacidosis are additional concerns with this combination.
How serious is the interaction between Ertugliflozin and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin dose when ertugliflozin is added and monitor blood glucose closely. Check for ketosis if the patient becomes unwell.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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