Drug interactions
Ertugliflozin + Insulin degludec
Severity: Moderate
Ertugliflozin and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ertugliflozin lowers blood glucose through urinary glucose excretion, and adding it to insulin therapy can increase the risk of hypoglycemia. Volume depletion and ketoacidosis are additional concerns when SGLT2 inhibitors are combined with insulin dose reductions.
What this interaction means in plain words
Ertugliflozin and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Insulin degludec belongs to Endocrine.
Why it happens
Additive glucose-lowering effect from insulin-mediated glucose uptake plus insulin-independent renal glucose loss.
What to do
Consider reducing the insulin dose when starting ertugliflozin and monitor blood glucose closely. Avoid abrupt or excessive insulin reduction and watch for ketoacidosis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
Frequently asked questions
Can I take Ertugliflozin with Insulin degludec?
MediHelp rates the interaction as moderate. Ertugliflozin and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ertugliflozin lowers blood glucose through urinary glucose excretion, and adding it to insulin therapy can increase the risk of hypoglycemia. Volume depletion and ketoacidosis are additional concerns when SGLT2 inhibitors are combined with insulin dose reductions.
How serious is the interaction between Ertugliflozin and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when starting ertugliflozin and monitor blood glucose closely. Avoid abrupt or excessive insulin reduction and watch for ketoacidosis symptoms.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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