Drug interactions
Ertugliflozin + Insulin glulisine
Severity: Moderate
Ertugliflozin and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ertugliflozin lowers glucose by increasing urinary glucose loss, which adds to insulin's effect and raises the risk of hypoglycemia. Patients on mealtime insulin may need a dose reduction.
What this interaction means in plain words
Ertugliflozin and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Insulin glulisine belongs to Endocrine.
Why it happens
Additive glucose lowering from SGLT2 inhibition and exogenous insulin.
What to do
Consider lowering the insulin glulisine dose when starting ertugliflozin and monitor glucose closely. Avoid abrupt large insulin reductions because of ketoacidosis risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
Frequently asked questions
Can I take Ertugliflozin with Insulin glulisine?
MediHelp rates the interaction as moderate. Ertugliflozin and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ertugliflozin lowers glucose by increasing urinary glucose loss, which adds to insulin's effect and raises the risk of hypoglycemia. Patients on mealtime insulin may need a dose reduction.
How serious is the interaction between Ertugliflozin and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin glulisine dose when starting ertugliflozin and monitor glucose closely. Avoid abrupt large insulin reductions because of ketoacidosis risk.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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